Reproductive Proteomics Comes of Age

Reproductive technology comes of age.

Graft-versus-host disease: proteomics comes of age.

In this issue of Blood, Paczesny and colleagues describe a set of 4 serum proteins that may help to confirm the diagnosis of acute GVHD and seem to be associated with worse survival independently of GVHD grade. Acute graft-versus-host disease (GVHD), the main complication of allogeneic hematopoietic cell transplantation, is mainly diagnosed clinically and can be confirmed by biopsy of 1 of the ...

Glyceroneogenesis comes of age.

Glyceroneogenesis is a generally ignored metabolic pathway that occurs in adipose tissues and liver of mammalian species. This short review highlights a series of recent discoveries showing that glyceroneogenesis is important in lipid homeostasis.

Immunosenescence comes of age

Introduction Ageing of the immune system (immunosenescence) contributes to the increased susceptibility of the elderly to infectious disease and to the poor outcome of vaccination. Defence against pathogens is compromised mainly because of changes in adaptive immunity mediated by T and B lymphocytes; however, all components of the immune system are affected (Fig 1). Dissecting the crucial alter...

Methylglyoxal Comes of AGE

The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression.